原著論文
Tatsuyuki Fukui, Asuka Terashima, Yasunori Omata, Ryota Chijimatsu, Kazuo Okamoto, Masayuki Tsukasaki, Yukiko Fukuda, Tadayoshi Hayata, Akiyoshi Saitoh, Etsuko Toda, Hiroshi Takayanagi, Sakae Tanaka, Yuya Terashima, Taku Saito
Disulfiram ameliorates bone loss in ovariectomized mice by suppressing osteoclastogenesis
Journal of Bone and Mineral Metabolism, 2024 Online ahead of print.
Ryunosuke Muro, Takeshi Nitta, Sachiko Nitta, Masayuki Tsukasaki, Tatsuo Asano, Kenta Nakano, Tadashi Okamura, Tomoki Nakashima, Kazuo Okamoto and Hiroshi Takayanagi
Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity
Journal of Clinical Investigation, 134:e179612, 2024
Kazutaka Nakamura, Masayuki Tsukasaki, Takaaki Tsunematsu, Minglu Yan, Yutaro Ando, Nam Cong-Nhat Huynh, Kyoko Hashimoto, Qiao Gou, Ryunosuke Muro, Ayumi Itabashi, Takahiro Iguchi, Kazuo Okamoto, Takashi Nakamura, Kenta Nakano, Tadashi Okamura, Tomoya Ueno, Kosei Ito, Naozumi Ishimaru, Kazuto Hoshi, Hiroshi Takayanagi
The periosteum provides a stromal defence against cancer invasion into the bone
Nature. 634:474-481, 2024
Yutaro Ando, Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Shizao Zang, Minglu Yan, Ryunosuke Muro, Kazutaka Nakamura, Masatsugu Komagamine, Noriko Komatsu, Kazuo Okamoto, Kenta Nakano, Tadashi Okamura, Akira Yamaguchi, Kazuyuki Ishihara, Hiroshi Takayanagi
The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis
International Journal of Oral Science. 16:18, 2024
Masatsugu Komagamine, Noriko Komatsu, Rui Ling, Kazuo Okamoto, Shi Tianshu, Kotaro Matsuda, Tsutomu Takeuchi, Yuko Kaneko and Hiroshi Takayanagi
Effect of JAK inhibitors on the three forms of bone damage in autoimmune arthritis: joint erosion, periarticular osteopenia, and systemic bone loss.
Inflammation and Regeneration. 43:44, 2023
Minglu Yan, Tsukasaki Masayuki, Ryunosuke Muro, Noriko Komatsu, Takeshi Nitta, Tadashi Okamura, Kazuo Okamoto, Yutaro Ando, and Kazutaka Nakamura Hiroshi Takayanagi
Identification of an intronic enhancer regulating RANKL expression in osteocytic cells
Bone Research, 11: 43, 2023
Minglu Yan, Noriko Komatsu, Ryunosuke Muro, Nam Huynh, Yoshihiko Tomofuji, Yukinori Okada, Hiroshi Suzuki, Hiroyuki Takaba, Riko Kitazawa, Sohei Kitazawa, Warunee Pluemsakunthai, Yuichi Mitsui, Takashi Satoh, Tadashi Okamura, Takeshi Nitta, Sin-Hyeog Im, Chan Johng Kim, George Kollias, Sakae Tanaka, Kazuo Okamoto, Masayuki Tsukasaki and Hiroshi Takayanagi.
ETS1 governs pathological tissue remodeling programs in disease-associated fibroblasts
Nature Immunology, 23: 1330-1341, 2022.
Takehito Ono, Ryosuke Denda, Yuta Tsukahara, Takashi Nakamura, Kazuo Okamoto, Hiroshi Takayanagi and Tomoki Nakashima.
Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1a signaling
Bone Research. 10:52. 2022.
Masayuki Tsukasaki, Noriko Komatsu, Takako Negishi-Koga, Nam Cong-Nhat Huynh, Ryunosuke Muro, Yutaro Ando, Yuka Seki, Asuka Terashima, Warunee Pluemsakunthai, Takeshi Nitta, Takashi Nakamura, Tomoki Nakashima, Shinsuke Ohba, Haruhiko Akiyama, Kazuo Okamoto, Roland Baron and Hiroshi Takayanagi.
Periosteal stem cells control growth plate stem cells during postnatal skeletal growth
Nature Communications, 13: 4166, 2022
Mikhail M Kostik, Maria A Makhova, Alexei S Maletin, Shamai M Magomedova, Lybov S Sorokina, Masayuki Tsukasaki, Kazuo Okamoto, Hiroshi Takayanagi, Dmitriy S Vasiliev, Darya I Kozlova, Alexander Yu Mushkin.
Cytokine profile in patients with chronic non-bacterial osteomyelitis, juvenile idiopathic arthritis, and insulin-dependent diabetes mellitus
Cytokine, 143: 155521, 2021
Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Kazuo Okamoto, Ryunosuke Muro, Asuka Terashima, Yoshitaka Kurikawa, Noriko Komatsu, Warunee Pluemsakunthai, Takeshi Nitta, Takaya Abe, Hiroshi Kiyonari, Tadashi Okamura, Mashito Sakai, Toshiya Matsukawa, Michihiro Matsumoto, Yasuhiro Kobayashi, Josef M. Penninger and Hiroshi Takayanagi
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution
Nature Metabolism, 2: 1382-1390, 2020
Masayuki Tsukasaki, Tatsuo Asano, Ryunosuke Muro, Nam Cong-Nhat Huynh, Noriko Komatsu, Kazuo Okamoto, Kenta Nakano, Tadashi Okamura, Takeshi Nitta and Hiroshi Takayanagi
OPG production matters where it happened
Cell Reports, 32: 108124, 2020
Tatsuo Asano, Kazuo Okamoto*, Yuta Nakai, Masanori Tsutsumi, Ryunosuke Muro, Ayako Suematsu, Kyoko Hashimoto, Tadashi Okamura, Shogo Ehata, Takeshi Nitta and Hiroshi Takayanagi* (*: corresponding authors)
Soluble RANKL is physiologically dispensable but accelerates tumor metastasis to bone.
Nature Metabolism, 1: 868-875, 2019
Mikihito Hayashi, Tomoki Nakashima, Noriko Yoshimura, Kazuo Okamoto, Sakae Tanaka and Hiroshi Takayanagi
Autoregulation of osteocyte Sema3A orchestrates estrogen action and counteracts bone aging
Cell Metabolism, 29: 1-11, 2019
Yuta Nakai, Kazuo Okamoto*, Asuka Terashima, Shogo Ehata, Jun Nishida, Takeshi Imamura, Takashi Ono and Hiroshi Takayanagi* (*: corresponding authors)
Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis
Bone Research, 7: 1, 2019
Maia Inoue, Kazuo Okamoto, Asuka Terashima, Takeshi Nitta, Ryunosuke Muro, Takako Negishi-Koga, Toshio Kitamura, Tomoki Nakashima, and Hiroshi Takayanagi
Arginine methylation controls the strength of γc family cytokine signaling in T cell maintenance
Nature Immunology, 19: 1265-1276, 2018
Masayuki Tsukasaki, Noriko Komatsu, Kazuki Nagashima, Takeshi Nitta, Warunee Pluemsakunthai, Chisa Shukunami, Yoichiro Iwakura, Tomoki Nakashima, Kazuo Okamoto, and Hiroshi Takayanagi
Host defense against oral microbiota by bone-damaging T cells
Nature Communications, 9: 701, 2018
Masayuki Tsukasaki*, Koki Hamada*, Kazuo Okamoto, Kazuki Nagashima, Asuka Terashima, Noriko Komatsu, Stephanie Win, Tadashi Okamura, Takeshi Nitta, Hisataka Yasuda, Josef M. Penninger and Hiroshi Takayanagi *equally contributed
LOX fails to substitute for RANKL in osteoclastogenesis
Journal of Bone and Mineral Research, 32: 434-439, 2017
Asuka Terashima, Kazuo Okamoto, Tomoki Nakashima, Shizuo Akira, Koichi Ikuta and Hiroshi Takayanagi
Sepsis-induced osteoblast ablation causes immunodeficiency
Immunity, 44: 1434-43, 2016
Takehito Ono, Kazuo Okamoto, Tomoki Nakashima, Takeshi Nitta, Shohei Hori, Yoichiro Iwakura and Hiroshi Takayanagi
IL-17-producing γδT cells enhance bone regeneration
Nature Communications, 7: 10928, 2016
Matteo M. Guerrini, Kazuo Okamoto, Noriko Komatsu, Shinichiro Sawa, Lynett Danks, Josef M. Penninger, Tomoki Nakashima and Hiroshi Takayanagi
Inhibition of the TNF family cytokine RANKL prevents autoimmune inflammation in the central nervous system
Immunity, 43: 1174-85, 2015
Takako Negishi-Koga, Hans-Jürgen Gober, Eriko Sumiya, Noriko Komatsu, Kazuo Okamoto, Shinichiro Sawa, Ayako Suematsu, Tomomi Suda, Kojiro Sato, Toshiyuki Takai and Hiroshi Takayanagi
Immune complexes regulate bone metabolism through FcRg signaling
Nature Communications, 6: 6637, 2015
Yasunori Omata, Tetsuro Yasui, Jun Hirose, Naohiro Izawa, Yuuki Imai, Takumi Matsumoto, Hironari Masuda, Naoto Tokuyama, Shuichi Tsutsumi, Takanori Fujita, Hisataka Yasuda, Kazuo Okamoto, Hiroshi Takayanagi, Atsuhiko Hikita, Takeshi Imamura, Koichi Matsuo, Taku Saito, Yuho Kadono, Hiroyuki Aburatani, and Sakae Tanaka
Genome-wide comprehensive analysis reveals critical cooperation between Smad and c-Fos in RANKL-induced osteoclastogenesis
Journal of Bone and Mineral Research, 30:869-877, 2015
Noriko Komatsu, Kazuo Okamoto, Shinichiro Sawa, Tomoki Nakashima, Masatsugu Oh-hora, Tatsuhiko Kodama, Sakae Tanaka, Jeffrey A. Bluestone and Hiroshi Takayanagi
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.
Nature Medicine, 20: 62-68,2014
Jun-ichi Furusawa, Kazuyo Moro, Yasutaka Motomura, Kazuo Okamoto, Jinfang Zhu, Hiroshi Takayanagi, Masato Kubo and Shigeo Koyasu
Critical Role of p38 and GATA3 in Natural Helper Cell Function.
The Journal of Immunology, 191: 1818-26, 2013
Erik Idrus, Tomoki Nakashima, Ling Wang, Mikihito Hayashi, Kazuo Okamoto, Tatsuhiko Kodama, Nobuyuki Tanaka, Tadatsugu Taniguchi and Hiroshi Takayanagi
The Role of the BH3-only Protein Noxa in Bone Homeostasis
Biochemical and Biophysical Research Communications, 410: 620-625, 2011
Kazuo Okamoto, Yoshiko Iwai, Masatsugu Oh-hora, Masahiro Yamamoto, Tomohiro Morio, Kazuhiro Aoki, Keiichi Ohya, Anton M. Jetten, Shizuo Akira, Tatsushi Muta and Hiroshi Takayanagi
IκBζ regulates TH17 development by cooperating with ROR nuclear receptors
Nature, 464: 1381-1385, 2010
Masahiro Shinohara, Takako Koga, Kazuo Okamoto, Shinya Sakaguchi, Kimiko Arai, Hisataka Yasuda, Toshiyuki Takai, Tatsuhiko Kodama, Tomohiro Morio, Raif S. Geha, Daisuke Kitamura, Tomohiro Kurosaki, Wilfried Ellmeier and Hiroshi Takayanagi
Tyrosine Kinases Btk and Tec Regulate Osteoclast Differentiation by Linking RANK and ITAM Signals
Cell, 132: 794-806, 2008
Masataka Asagiri, Toshitake Hirai, Toshihiro Kunigami, Shunya Kamano, Hans-Jürgen Gober, Kazuo Okamoto, Keizo Nishikawa, Eicke Latz, Douglas T. Golenbock, Kazuhiro Aoki, Keiichi Ohya, Yuuki Imai, Yasuyuki Morishita, Kohei Miyazono, Shigeaki Kato, Paul Saftig and Hiroshi Takayanagi
Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis
Science, 319: 624-627, 2008
Kojiro Sato, Ayako Suematsu, Kazuo Okamoto, Akira Yamaguchi, Yasuyuki Morishita, Yuho Kadono, Sakae Tanaka, Tatsuhiko Kodama, Shizuo Akira, Yoichiro Iwakura, Daniel J. Cua and Hiroshi Takayanagi
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
Journal of Experimental Medicine 203: 2673-2682, 2006
Takuya Yamamoto, Miki Ebisuya, Fumito Ashida, Kazuo Okamoto, Shin Yonehara and Eisuke Nishida
Continuous ERK Activation Downregulates Anti-proliferative Genes throughout G1 Phase to Allow Cell Cycle Progression
Current Biology, 16: 1171-1182, 2006
Kazuo Okamoto, Jun-ichi Fujisawa, Michael Reth and Shin Yonehara
Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kB
Genes to Cells, 11: 177-191, 2006
Kozo Watanabe, Kazuo Okamoto and Shin Yonehara
Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP
Cell Death and Differentiation, 12: 10-18, 2005
英文総説
Kazuo Okamoto
Crosstalk between bone and the immune system
Journal of Bone and Mineral Metabolism. 42:470-480, 2024
Kazuo Okamoto* and Hiroshi Takayanagi (*: corresponding authors)
Effect of T cells on bone
Bone. 168:116675, 2023.
Kazuo Okamoto
Role of RANKL in cancer development and metastasis
Journal of Bone and Mineral Metabolism, 39: 71-81, 2021
Kazuo Okamoto and Hiroshi Takayanagi
Osteoimmunology
Cold Spring Harbor Perspectives in Medicine, 9:1, 2019
Kazuo Okamoto and Hiroshi Takayanagi
Osteoimmunology
Genetics of Bone Biology and Skeletal Disease, Second Edition, 261-282, 2017 (ACADEMIC PRESS/ ELSEVIER)
Kazuo Okamoto, Tomoki Nakashima, Masahiro Shinohara, Takako Negishi-Koga, Noriko Komatsu, Asuka Terashima, Shinichiro Sawa, Takeshi Nitta and Hiroshi Takayanagi
Osteoimmunology: the conceptual framework unifying the immune and skeletal systems
Physiological Reviews, 97: 1295-1349, 2017
Kazuo Okamoto and Hiroshi Takayanagi
Potential molecular targets for suppressing Th17 development
Inflammation and Regeneration, 31: 354-360, 2011
Kazuo Okamoto and Hiroshi Takayanagi
Regulation of bone by the adaptive immune system in arthritis
Arthritis Research & Therapy, 13: 219, 2011
Kazuo Okamoto and Hiroshi Takayanagi
Osteoclasts and interleukin-17-producing helper T cells in rheumatoid arthritis
Arthritis: Pathophysiology, Prevention and Therapeutics, 75-89, 2011
Kazuo Okamoto and Hiroshi Takayanagi
Osteoclasts in arthritis and Th17 development
International Immunopharmacology, 11: 543-548, 2011
日本語総説
岡本一男、小守壽文、高柳広、林幹人、福本誠二 「骨サミット 座談会・オステオネットワーク研究の課題と展望」 骨・軟骨・筋科学Update (日本骨代謝学会学術刊行誌)、第7号、2024(2024年12月)
岡本一男 「RANKL biology」 骨・軟骨・筋科学Update (日本骨代謝学会学術刊行誌)、第6号、2024(2024年3月)
岡本一男、高柳広 「骨におけるT細胞の役割」 リウマチ科 (科学評論社)、Vol.71 No.1、2024(2024年1月)
岡本一男 「骨免疫学とオステオネットワーク」 生体の科学、Vol.74 No.6、2023
岡本一男 「学会レポート:第31回 日本医学会総会(2023東京)」 感染・炎症・免疫、第53巻 第2号、2023
岡本一男、高柳広 「骨免疫学の20年 〜骨と免疫の接点から骨免疫系の確立へ〜」 感染 炎症 免疫 Vol.50 No.2 Autumn 2020 p22-32, 2020
岡本一男 「骨と免疫、がんにおける可溶型RANKL」 日本臨床リウマチ学会雑誌 臨床リウマチ (Clin Rheumatol Rel Res), 31: 336-342, 2019
岡本一男、高柳広 「炎症疾患における骨の障害と修復機構」 別冊BIO Clinica 慢性炎症と疾患 通巻22号 第8巻第1巻p55-60, 2019
岡本一男 「IL-17産生性T細胞による骨の制御」日本臨床免疫学会会誌 40巻5号 p361-366, 2017
岡本一男、高柳広 「Overview – その研究の新たな潮流」THE BONE 特集 『骨免疫学の進歩が変える骨関節疾患アプローチ』 Vol.31 No.2, p19-28, 2017年6月号
岡本一男、Matteo M. Guerrini、高柳広 「EAEの中枢神経炎症におけるRANKLとT細胞の役割」 臨床免疫・アレルギー科『特集II．臓器特異的自己免疫疾患研究の進歩』9月号, 66(3), 2016
岡本一男、Matteo M. Guerrini、高柳広 「多発性硬化症におけるRANKLの役割」 月刊「細胞」分子細胞生物学講座コーナー 6月号, 2016
岡本一男、高柳広 「骨免疫学」 研修ノートシリーズ 『膠原病・リウマチ・アレルギー研修ノート』(株式会社 診断と治療社) 2016年4月
岡本一男、高柳広 「免疫系におけるRANKLの役割」 単行本 『ファーマナビゲーターシリーズ 抗RANKL抗体編』(株式会社 メディカルレビュー社) 2015年5月
岡本一男、高柳広 「リウマチの関節破壊と骨粗鬆化の共通点、相違点」 単行本 『関節リウマチと骨粗鬆症−内科医が実践すべき診断と治療−』 (株式会社 医薬ジャーナル社) 2015年
岡本一男、高柳広 「T細胞と骨破壊・骨形成」 THE BONE 『骨代謝調節の新たな展開』 10月号 Vol.27 No.4
岡本一男、高柳広 「骨の研究最前線 骨免疫学」 HORMONE FRONTIER IN GYNECOLOGY 第79号 (Vol.20 No.3 2013 9月号)
岡本一男、高柳広 「骨免疫学 − オーバービュー」, CLINICAL CALCIUM, 22 (11): 1641-1649, 2012
岡本一男、高柳広 「第IV部 学術的免疫研究の展開 26. 骨免疫学の新展開」 免疫学update −分子病態の解明と治療への展開−、2012
岡本一男、高柳広 「骨免疫学の歴史と新たな展開」, 領域融合レビュー (オンラインジャーナル: http://leading.lifesciencedb.jp/1-e003/), 2012
岡本一男 「骨免疫学-研究最前線 骨と免疫系のクロストーク 3.転写因子NFATc1と破骨細胞」, 医学のあゆみ、242 (9): 655-659, 2012
岡本一男、高柳広 「転写制御因子IkBzによるTh17細胞分化制御」 Frontiers in Rheumatology & Clinical Immunology, 5 (2): 53-57, 2011
岡本一男、高柳広 「転写制御因子IkBzを標的としたTh17細胞制御」 最新医学, 66 (2): 287-292, 2011
岡本一男、高柳広 「Th17細胞分化に必須の転写制御因子IkBz」 医学のあゆみ, 236 (8): 803-804, 2011
岡本一男、高柳広「Th17細胞と転写制御因子IkBz」 生物の科学 遺伝, 65 (2): 78-82, 2011
岡本一男、高柳広 「自己免疫疾患を引き起こすT細胞の運命を決定する遺伝子を同定」 整形外科, 61 (13): 1410, 2010
岡本一男、高柳広 「骨代謝とサイトカイン―関節リウマチにおける免疫系による骨代謝制御―」 実験医学 28（12）：196-202、2010
岡本一男 「TLRシグナルと骨免疫学」 THE BONE 23（4）(10月号)：61-68、2009
岡本一男、高柳広 「自己免疫性関節炎とカテプシンKの関連を探る」 分子リウマチ治療 2 (4): 13-18、2009
岡本一男、高柳広 「自己免疫疾患にかかわるcathepsin Kの新たな役割」 実験医学 26（20）：182-187、2008
岡本一男、高柳広 「炎症性骨破壊におけるTh17細胞の役割—Th17細胞による破骨細胞制御のメカニズム」 医学のあゆみ 226（4）： 291-294、2008
岡本一男、米原伸 「デスレセプターとDISC関連分子」 実験医学 22 (11)：25-30、2004
岡本一男、米原伸 「TNF/Fasファミリーによるアポトーシス誘導機構」 わかる実験医学シリーズ「サイトカインがわかる」：58-66、2002